Bioinformatic Expansion and Discovery of Thiopeptide Antibiotics
نویسندگان
چکیده
منابع مشابه
Solution structures of thiopeptide antibiotics.
A detailed NMR study of the thiopeptide amythiamicin D establishes its solution conformation and the presence of a single intramolecular hydrogen bond involving NH13 and O28, and also provides the first evidence for self-association of thiopeptides in solution.
متن کاملThiopeptide Antibiotics: Retrospective and Recent Advances
Thiopeptides, or thiazolyl peptides, are a relatively new family of antibiotics that already counts with more than one hundred different entities. Although they are mainly isolated from soil bacteria, during the last decade, new members have been isolated from marine samples. Far from being limited to their innate antibacterial activity, thiopeptides have been found to possess a wide range of b...
متن کاملThiopeptide antibiotics stimulate biofilm formation in Bacillus subtilis.
Bacteria have evolved the ability to produce a wide range of structurally complex natural products historically called "secondary" metabolites. Although some of these compounds have been identified as bacterial communication cues, more frequently natural products are scrutinized for antibiotic activities that are relevant to human health. However, there has been little regard for how these comp...
متن کاملBioinformatic discovery of novel bioactive peptides.
Short synthetic oligopeptides based on regions of human proteins that encompass functional motifs are versatile reagents for understanding protein signaling and interactions. They can either mimic or inhibit the parent protein's activity and have been used in drug development. Peptide studies typically either derive peptides from a single identified protein or (at the other extreme) screen rand...
متن کاملThiopeptide Antibiotics Act on Both Host and Microbe to Deliver Double Punch on Mycobacterial Infection
Mycobacterial infection has long been one of the most serious infectious diseases throughout the world. Since the abuse of antibiotics, and for other reasons, the emergence of bacterial drug-resistance is now one of the most urgent clinical problems. Nowadays, the speed of antibiotic development is actually far more slowly than that of the bacterial drug-resistance generation. Thereby, searchin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2018
ISSN: 0002-7863,1520-5126
DOI: 10.1021/jacs.8b03896